Asarone inhibits adipogenesis and stimulates lipolysis in 3T3-L1 adipocytes

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Asarone inhibits adipogenesis and stimulates lipolysis in 3T3-L1 adipocytes
S H Lee; K Y Kim; S Y Ryu; Y Yoon; D H Hahm; S A Kang; S H Cho; J S Lim; E Y Moon; Suk Ran YoonHee Gu Lee; D Y Yoon; Y Yang
Bibliographic Citation
Cellular and Molecular Biology, vol. 56, no. 3, pp. 1215-1222
Publication Year
Asarone is a molecule found in certain plants such as Acorus calamus, the root of which is used in traditional medicine to treat diabetes. We determined the molecular mechanism underlying the anti-diabetic activity of asarone. Treatment of asarone significantly inhibited the differentiation of 3T3-L1 preadipocytes through suppression of expression of the transcription factors, CCAAT/enhancer binding protein-α and peroxisome proliferator activated receptor-γ, which activate adipogenesis. Intracellular triglyceride levels were reduced by asarone in a dose-dependent manner and asarone treatment stimulated the phosphorylation of hormone-sensitive lipase. Together, the present findings indicate that asarone inhibits adipogenesis by down-regulation of PPARγ and C/EBPα and reduces lipid accumulation by stimulation of lipolysis through an increase in hormone-sensitive lipase activity.
C/EBPαPPARγAdiponectinAsaroneHormone-sensitive lipase
C M B Assoc
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Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
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