ACAT (Acyl-CoA:cholesterol Acyltransferase) inhibitory effect and quantification of pyranocurmarin in different parts of Angelica gigas nakai = 참당귀(Angelica gigas)에서 분리한 pyranocurmarin 성분의 ACAT 저해활성 및 부위별 pyranocurmarin 성분의 함량 분석

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Title
ACAT (Acyl-CoA:cholesterol Acyltransferase) inhibitory effect and quantification of pyranocurmarin in different parts of Angelica gigas nakai = 참당귀(Angelica gigas)에서 분리한 pyranocurmarin 성분의 ACAT 저해활성 및 부위별 pyranocurmarin 성분의 함량 분석
Author(s)
G S Kim; C G Park; Tae Sook Jeong; S W Cha; N I Baek; K S Song
Bibliographic Citation
Journal of Applied Biological Chemistry, vol. 52, no. 4, pp. 187-194
Publication Year
2009
Abstract
Two pyranocoumarin constituents have been isolated from Angelica gigas and were identified as decursinol angelate (1) and decursin (2) by means of NMR analysis, respectively. Human acyl-CoA: cholesterol acyltransferase (hACAT) inhibitory activity of decursinol angelate (1) and decursin (2) was evaluated. Decursin (2) showed significantly inhibitory activity against hACAT1 and hACAT2 with IC50 value of 137 and 168 μM, respectively, whereas decursinol angelate (1) exhibited weak ACAT inhibitory activity. These results suggested that decusin from A. gigas might be effective for the prevention and the treatment of hypercholesterolemia or atherosclerosis by inhibitory effect on hACAT. The contents of decursinol angelate (1) and decursin (2) were analyzed in various parts of A. gigas including flower, seed, leaf and root using LC/MS/MS (ESI, positive ion mode, MRM mode). The content of decursinol angelate was increased in order of flower, seed, leaf, and root and decursin content was increased in order of flower, seed, leaf, and root. It was expected that unused parts including leaf and flower of A. gigas might be useful as new functional sources by their high contents of decursin and decursinol angelate.
Keyword
ACAT (Acyl-CoA:cholesterol acyltransferase)Angelica gigasdecursindecursinol angelateLC/MS/MS
ISSN
1229-2737
Publisher
Springer
DOI
http://dx.doi.org/10.3839/jabc.2009.032
Type
Article
Appears in Collections:
Division of Biomaterials Research > Industrial Bio-materials Research Center > 1. Journal Articles
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