Open Access@KRIBBDivision of Research on National ChallengesInfectious Disease Research Center1. Journal Articles
Isolation and identification of FR198248, a hydroxylated 1,4-dihydroisobenzofuran, from Aspergillus flavipes F543 as an inhibitor of peptide deformylase = Aspergillus flavipes균주로 부터 PDF 저해제 FR198248의 분리 및 동정
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- Title
- Isolation and identification of FR198248, a hydroxylated 1,4-dihydroisobenzofuran, from Aspergillus flavipes F543 as an inhibitor of peptide deformylase = Aspergillus flavipes균주로 부터 PDF 저해제 FR198248의 분리 및 동정
- Author(s)
- Yun-Ju Kwon; C J Zheng; Won Gon Kim
- Bibliographic Citation
- Bioscience Biotechnology and Biochemistry, vol. 74, no. 2, pp. 390-393
- Publication Year
- 2010
- Abstract
- Two highly hydroxylated 1,3-dihydroisobenzofurans, FR198248 (1) and FR202306 (2), were isolated as peptide deformylase (PDF) inhibitors from Aspergillus flavipes. Compounds 1 and 2 inhibited Staphylococus aureus PDF with IC50 values of 3.6 and 2.5 μM, respectively, and also showed antibacterial activity with an MIC value of 25 μg/ml. In contrast, 6-O-methyl derivative 3 of compound 2 was inactive against both PDF and S. aureus.
- Keyword
- 1,3-dihydroisobenzofuranAntibacterialAspergillus flavipesPeptide deformylaseStaphylococcus aureus
- ISSN
- 0916-8451
- Publisher
- T&F (Taylor & Francis)
- Type
- Article
- Appears in Collections:
- Division of Research on National Challenges > Infectious Disease Research Center > 1. Journal Articles
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