Potent anticariogenic activity of Aceriphyllum rossii and its components, aceriphyllic acid A and 3-oxoolean-12-en-27-oic acid = 돌단풍과 Aceriphyllic acid A 물질의 항충치 활성

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Title
Potent anticariogenic activity of Aceriphyllum rossii and its components, aceriphyllic acid A and 3-oxoolean-12-en-27-oic acid = 돌단풍과 Aceriphyllic acid A 물질의 항충치 활성
Author(s)
C J Zheng; Hyun Woo OhWon Gon Kim
Bibliographic Citation
Journal of Food Science, vol. 75, no. 2, pp. M78-M82
Publication Year
2010
Abstract
Aceriphyllum rossii Engler (Saxifragaceae) have been used as a nutritious food in Korea. We found that the methanol extract of A. rossii root and its components, aceriphyllic acid A and 3-oxoolean-12-en-27-oic acid, potently inhibited the growth of the key cariogenic bacteria, Streptococcus mutans, with MIC of 2 to 4 μg/mL. They also showed antibacterial activity against other cariogenic bacteria such as S. oralis, S. sobrinus, and S. salivarius with the similar potency. In the time-kill study, aceriphyllic acid A reduced the viable counts of S. mutans by 90% in 1 min at 8 μg/mL, indicating that aceriphyllic acid A had the fast bacteriostatic activity. Severe damages of the cell surface of S. mutans by aceriphyllic acid A were observed by transmission electron microscopy, suggesting with its fast antibacterial activity that its mechanism of action might be membrane disruption. These results suggest that the methanol extract of A. rossii root and its components, aceriphyllic acid A and 3-oxoolean-12-en-27-oic acid, could have the great potential as natural agents for preventing dental caries.
Keyword
3-oxoolean-12-en-27-oic acidaceriphyllic acid AAceriphyllum rossiianticariogenic activityStreptococcus mutans
ISSN
0022-1147
Publisher
Wiley
DOI
http://dx.doi.org/10.1111/j.1750-3841.2009.01476.x
Type
Article
Appears in Collections:
Division of Bio Technology Innovation > Core Facility Management Center > 1. Journal Articles
Division of Research on National Challenges > Infectious Disease Research Center > 1. Journal Articles
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