Bioactive metabolites from the sponge-derived fungus Aspergillus versicolor

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Title
Bioactive metabolites from the sponge-derived fungus Aspergillus versicolor
Author(s)
Y M Lee; H Li; J Hong; H Y Cho; Kyung Sook Bae; M A Kim; D K Kim; J H Jung
Bibliographic Citation
Archives of Pharmacal Research, vol. 33, no. 2, pp. 231-235
Publication Year
2010
Abstract
As part of an ongoing search for bioactive metabolites from the fungus Aspergillus versicolor derived from a marine sponge Petrosia sp., an aromatic polyketide derivative (1), two xanthones (2 and 3), and five anthraquinones (4-8) were isolated by bioactivity-guided fractionation. The gross structures were determined based on the NMR and MS spectroscopic data, and the absolute configurations were defined by comparison of optical rotation data with those of reported. Compounds 2, 4, 5, and 7 exhibited significant cytotoxicity against five human solid tumor cell lines (A-549, SK-OV-3, SK-MEL-2, XF-498, and HCT-15) with IC50 values in the range of 0.41-4.61 μg/mL. Compounds 4 and 7 exhibited antibacterial activity against several clinically isolated Gram-positive strains with MIC values of 0.78-6.25 μg/mL.
Keyword
AnthraquinoneAntibacterial activityAspergillus versicolorCytotoxicityPolyketideXanthone
ISSN
0253-6269
Publisher
Pharmaceutical Soc Korea
DOI
http://dx.doi.org/10.1007/s12272-010-0207-4
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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