TXNIP regulates germinal center generation by suppressing BCL-6 expression

Cited 8 time in scopus
Metadata Downloads
Title
TXNIP regulates germinal center generation by suppressing BCL-6 expression
Author(s)
Y Shao; S Y Kim; D Shin; Mi-Sun Kim; Hyun-Woo Suh; Z H Piao; M Jeong; Suk Hyung Lee; Suk Ran Yoon; B H Lim; W H Kim; J K Ahn; In Pyo Choi
Bibliographic Citation
Immunology Letters, vol. 129, no. 2, pp. 78-84
Publication Year
2010
Abstract
The detailed mechanism driving the germinal center (GC) reaction to B cell lymphomagenesis has not been clarified. Thioredoxin interacting protein (TXNIP), also known as vitamin D3 up-regulated protein 1 which is an important tumor repressor, is involved in stress responses, redox regulation, and cellular proliferation. Here, we report that TXNIP has a potential role in the formation of GC in peripheral lymphoid organs where B lymphocytes divide rapidly. First, we compared changes in GC from wild type mice and Txnip-/- mice. After immunization, Txnip-/- mice exhibited higher expression level of BCL-6 and larger percentage of GC B cells with the reduction in antibody production and plasma cell numbers. In addition, Txnip-/- spleens had a much larger population which expressed Ki-67, a marker of cell proliferation, in the red pulp border than WT spleens. Furthermore, the expression of BCL-6 was decreased in TXNIP overexpressing cells and elevated in TXNIP deficient cells. Taken together, we conclude that TXNIP may contribute to the formation of GCs after immunization. During this process, TXNIP suppresses BCL-6 expression.
Keyword
B cellsBCL-6Germinal centerTXNIP
ISSN
0165-2478
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.imlet.2010.02.002
Type
Article
Appears in Collections:
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.