Alkamides from Piper longum and Piper nigrum as inhibitors of IL-6 action = 필발 및 호초로부터 분리된 알카마이드화합물의 IL-6 저해활성

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Title
Alkamides from Piper longum and Piper nigrum as inhibitors of IL-6 action = 필발 및 호초로부터 분리된 알카마이드화합물의 IL-6 저해활성
Author(s)
Seung Woong Lee; Kim myo seon; Park Mi-hye; Su-Jin ParkWoo Song Lee; Jong Sun Chang; Mun Chual Rho
Bibliographic Citation
Bulletin of Korean Chemical Society, vol. 31, no. 4, pp. 921-924
Publication Year
2010
Abstract
Blocking of IL-6 has been postulated to be an effective therapy in the pathogenesis of several inflammatory diseases. The current study was performed to examine the potential effects of alkamides isolated from P. longum and P. nigrum on IL-6 induced Stat3 activation and identify the structure-activity relationship of these alkamides in human hepatoma cells. Among 10 alkamides isolated from P. longum and P. nigrum, compounds 6, 7 and 9 were identified as strong inhibitors of IL-6 action, which inhibit IL-6 induced Stat3-dependent luciferase activities. These inhibitory activities were positively influenced by the presence of piperidine moiety.
Keyword
Interleukin-6Piper longumPiper nigrumStat3
ISSN
0253-2964
Publisher
Wiley
DOI
http://dx.doi.org/10.5012/bkcs.2010.31.04.921
Type
Article
Appears in Collections:
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
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