Ellagic acid protects hepatocytes from damage by inhibiting mitochondrial production of reactive oxygen species

Cited 45 time in scopus
Metadata Downloads
Title
Ellagic acid protects hepatocytes from damage by inhibiting mitochondrial production of reactive oxygen species
Author(s)
J M Hwang; J S Cho; T H Kim; Young Ik Lee
Bibliographic Citation
Biomedicine & Pharmacotherapy, vol. 64, no. 4, pp. 264-270
Publication Year
2010
Abstract
The aim of this experiment is to investigate the antioxidative and antiapoptotic roles of ellagic (EA) acid in in vitro and in in vivo experiment. We measured protective properties of EA against oxidative stress-induced hepatocyte damage in vitro and Concanavalin (ConA)-induced liver damage in vivo. EA, a potent antioxidant, exhibited protective properties against oxidative stress-induced hepatocyte damage by preventing vitamin k3 (VK3)-induced reactive oxygen species (ROS) productions, apoptotic and necrotic cellular damage and mitochondrial depolarization, which is a main cause of ROS production. EA also protects against cell death and elevation of glutathione (GSH), alanine transaminase (ALT) and asparatate transaminase (AST) in Con A-induced fulminant liver damage in mice. These results show that antioxidant and cytoprotective properties of EA prevent liver damage induced by various type of oxidative stress.
Keyword
ApoptosisConcanavalin ACytoprotective effectEllagic acidMitochondrial depolarizationReactive oxygen species
ISSN
0753-3322
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.biopha.2009.06.013
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.