YC-1 enhances natural killer cell differentiation from hematopoietic stem cells

Cited 7 time in scopus
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Title
YC-1 enhances natural killer cell differentiation from hematopoietic stem cells
Author(s)
Sohyun Yun; Suk Hyung Lee; Yun Hee Kang; Mi-Ra Jeong; Mi-Joung Kim; Mi-Sun Kim; piaozhenghao; Hyun-Woo Suh; Tae-Don Kim; P K Myung; Suk Ran Yoon; In Pyo Choi
Bibliographic Citation
International Immunopharmacology, vol. 10, no. 4, pp. 481-486
Publication Year
2010
Abstract
NK cells play crucial roles in innate immunity and adaptive immunity. The detailed mechanisms, however, governing NK cell development remains unclear. In this study, we report that YC-1 significantly enhances NK cell populations differentiated from human umbilical cord blood hematopoietic stem cells (HSCs). NK cells increased by YC-1 display both phenotypic and functional features of fully mature NK (mNK) cells, but YC-1 does not affect the activation of mNK cells. YC-1 did not affect cGMP production and phosphorylation of STAT-5 which is essential for IL-15R signaling. On the other hand, YC-1 increased p38 MAPK phosphorylation during NK cell differentiation. Furthermore, p38 inhibitor SB203580 inhibited the differentiation of NK cells enhanced by YC-1. Taken together, these data suggest that YC-1 enhances NK cell differentiation through the activation of p38 MAPK which is involved in NK cell differentiation.
Keyword
DifferentiationHematopoietic stem cellsNK cellsp38YC-1
ISSN
1567-5769
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.intimp.2010.01.009
Type
Article
Appears in Collections:
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
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