Puzzling inefficiency of H5N1 influenza vaccines in Egyptian poultry

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Title
Puzzling inefficiency of H5N1 influenza vaccines in Egyptian poultry
Author(s)
Jeong Ki Kim; G Kayali; D Walker; H L Forrest; A H Ellebedy; Y S Griffin; A Rubrum; M M Bahgat; M A Kutkat; M A A Ali; J R Aldridge; N J Negovetich; S Krauss; R J Webby; R G Webster
Bibliographic Citation
Proceedings of National Academy of Sciences of United States of America, vol. 107, no. 24, pp. 11044-11049
Publication Year
2010
Abstract
In Egypt, efforts to control highly pathogenic H5N1 avian influenza virus in poultry and in humans have failed despite increased biosecurity, quarantine, and vaccination at poultry farms. The ongoing circulation of HP H5N1 avian influenza in Egypt has caused >100 human infections and remains an unresolved threat to veterinary and public health. Here,we describe that the failure of commercially available H5 poultry vaccines in Egyptmay be caused in part by the passive transfer of maternal H5N1 antibodies to chicks, inhibiting their immune response to vaccination. We propose that the induction of a protective immune response to H5N1 is suppressed for an extended period in young chickens. This issue, among others,must be resolved and additional steps must be taken before the outbreaks in Egypt can be controlled.
Keyword
ImmuneMaternally transferred antibodiesSuppression
ISSN
0027-8424
Publisher
Natl Acad Sciences
DOI
http://dx.doi.org/10.1073/pnas.1006419107
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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