New biological functions and applications of high-molecular-mass poly-gamma-glutamic acid

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Title
New biological functions and applications of high-molecular-mass poly-gamma-glutamic acid
Author(s)
Haryoung Poo; C Park; M S Kwak; D Y Choi; S P Hong; I H Lee; Y T Lim; Y K Choi; S R Bae; H Uyama; C J Kim; M H Sung
Bibliographic Citation
Chemistry & Biodiversity, vol. 7, no. 6, pp. 1555-1562
Publication Year
2010
Abstract
Ultra-high-molecular-weight poly-γ-glutamic acid (γ-PGA) is a most promising biodegradable polymer that is produced by Bacillus subtilis (chungkookjang). Attractive properties of γ-PGA are that it is water soluble, anionic, biodegradable, and edible. Development of γ-PGA has pursued in terms of cosmetics/skin care, bone care, nanoparticle for drug delivery system, hydrogel, and so on. Very recently, our research has shown that γ-PGA can be used as an immune-stimulating agent, especially at high molecular weight. This review presents the synthesis and production of high-molecular-weight γ-PGA and its various applications in industrial fields.
ISSN
1612-1872
Publisher
Wiley
DOI
http://dx.doi.org/10.1002/cbdv.200900283
Type
Article
Appears in Collections:
Division of Research on National Challenges > Infectious Disease Research Center > 1. Journal Articles
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