Newly identified tumor-associated role of human Sharpin

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Title
Newly identified tumor-associated role of human Sharpin
Author(s)
J Jung; J M Kim; B Park; Y Cheon; B Lee; S H Choo; Sang Seok Koh; S Lee
Bibliographic Citation
Molecular and Cellular Biochemistry, vol. 340, no. 1, pp. 161-167
Publication Year
2010
Abstract
In order to discover previously unidentified cancer-associated genes, we analyzed genome-wide differences in gene expression between tumor biopsies and normal tissues. Among those differentially regulated genes, we identified Sharpin (Shank-associated RH domain-interacting protein) as a commonly up-regulated gene in multiple human cancer types. Although rat Sharpin is reported to interact with Shank1, a multidomain scaffold protein localized in postsynaptic densities, its exact roles are unknown. Whereas human Sharpin homologue was primarily localized in the cytosol of cultured cells, they were detected in both cytosol and nucleus of the cells from ovarian and liver cancer tissues using immunohistochemical staining. In addition, Chinese ovary hamster cells over-expressing Sharpin exhibited enhanced cancer-specific phenotypes in multiple in vitro tumor assays. Taken together, the results suggest that Sharpin is not an inert scaffold protein, but may play tumor-associated roles during cancer biogenesis.
Keyword
ImmunohistochemistryInvasion assayOncogeneOncology databasePost-synaptic densityShank-associated RH domain-interacting protein
ISSN
0300-8177
Publisher
Springer
DOI
http://dx.doi.org/10.1007/s11010-010-0413-x
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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