Structure-activity relationship of indoline-2-carboxylic acid N-(substituted)phenylamide derivatives

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Title
Structure-activity relationship of indoline-2-carboxylic acid N-(substituted)phenylamide derivatives
Author(s)
J W Kwak; Y Kim; H Park; J Y Jang; K K Lee; W Yi; J A Kwak; Song Kyu Park; Hwan Mook Kim; Kiho Lee; Jong Soon Kang; S B Han; B Y Hwang; J T Hong; J K Jung; Y Kim; J Cho; H Lee
Bibliographic Citation
Bioorganic & Medicinal Chemistry Letters, vol. 20, no. 15, pp. 4620-4623
Publication Year
2010
Abstract
Chroman derivatives exhibited potent inhibitory activity of NF-κB. For SAR, the chroman scaffold was modified with an indoline moiety. A series of indoline-2-carboxylic acid N-(substituted)phenylamide derivatives were synthesized to explore their inhibitory activities of NF-κB and they were also evaluated for cytotoxicity against various cancer cell lines. Since intermediates with Boc showed outstanding results, various substituents in place of the Boc group were introduced additionally and these compounds were also evaluated for SAR.
Keyword
Cytotoxic activityIndoline-2-carboxamideNF-κB inhibitors
ISSN
0960-894X
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.bmcl.2010.06.004
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of Bioinfrastructure > Laboratory Animal Resource Center > 1. Journal Articles
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