Network analysis of hepatic genes responded to high-fat diet in C57BL/6J Mice: Nutrigenomics data mining from recent research findings

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Title
Network analysis of hepatic genes responded to high-fat diet in C57BL/6J Mice: Nutrigenomics data mining from recent research findings
Author(s)
E J Kim; E Kim; E Y Kwon; H S Jang; Cheol-Goo Hur; M S Choi
Bibliographic Citation
Journal of Medicinal Food, vol. 13, no. 4, pp. 743-756
Publication Year
2010
Abstract
Obesity and its associated complications, including diabetes, dyslipidemia, atherosclerosis, and some cancers, have been a global health problem with a rapid increase of the obese population. In this study, we selected 31 obesity candidate genes in the liver of high-fat-induced obese C57BL/6J mice through investigation of literature search and analyzed functional protein-protein interaction of the genes using the STRING database. Most of the obesity candidate genes were closely connected through lipid metabolism, and in particular acyl-coenzyme A oxidase 1 appeared to be a core obesity gene. Overall, genes involved in fatty acid β-oxidation, fatty acid synthesis, and gluconeogenesis were up-regulated, and genes involved in sterol biosynthesis, insulin signaling, and oxidative stress defense system were down-regulated with a high-fat diet. Future identification of core obesity genes and their functional targets is expected to provide a new way to prevent obesity by phytochemicals or functional foods on the basis of food and nutritional genomics.
Keyword
high-fat dietnutrigenomicsobesity
ISSN
1096-620X
Publisher
Mary Ann Liebert, Inc
DOI
http://dx.doi.org/10.1089/jmf.2009.1350
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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