Hydroxyhibiscone A, a novel human neutrophil elastase inhibitor from Hibiscus syriacus

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Title
Hydroxyhibiscone A, a novel human neutrophil elastase inhibitor from Hibiscus syriacus
Author(s)
In Ja Ryoo; B S Yun; I K Lee; Y H Kim; Ick Soo Lee; Jong Seog Ahn; K Bae; Ick Dong Yoo
Bibliographic Citation
Journal of Microbiology and Biotechnology, vol. 20, no. 8, pp. 1189-1191
Publication Year
2010
Abstract
In an ongoing investigation of compounds from natural products that exhibit anti-aging properties, hydroxyhibiscone A (1), a new furanosesquiterpenoid, together with hibiscone D (2), was isolated from the root bark of Hibiscus syriacus. Utilizing UV, IR, NMR, and MS spectroscopic analyses, these chemical structures were revealed. Compounds 1 and 2 were found to posses significant anti-aging properties on the human neutrophil elastase (HNE) assay, exhibiting HNE inhibitory activities with IC50 values of 5.2 and 4.6 μM, respectively.
Keyword
Hibiscus syriacusHuman neutrophil elastaseHydroxyhibiscone A
ISSN
1017-7825
Publisher
Korea Soc-Assoc-Inst
DOI
http://dx.doi.org/10.4014/jmb.1004.04028
Type
Article
Appears in Collections:
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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