Hydroxyhibiscone A, a novel human neutrophil elastase inhibitor from Hibiscus syriacus

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dc.contributor.authorIn Ja Ryoo-
dc.contributor.authorB S Yun-
dc.contributor.authorI K Lee-
dc.contributor.authorY H Kim-
dc.contributor.authorIck Soo Lee-
dc.contributor.authorJong Seog Ahn-
dc.contributor.authorK Bae-
dc.contributor.authorIck Dong Yoo-
dc.date.accessioned2017-04-19T09:19:29Z-
dc.date.available2017-04-19T09:19:29Z-
dc.date.issued2010-
dc.identifier.issn1017-7825-
dc.identifier.uri10.4014/jmb.1004.04028ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/9687-
dc.description.abstractIn an ongoing investigation of compounds from natural products that exhibit anti-aging properties, hydroxyhibiscone A (1), a new furanosesquiterpenoid, together with hibiscone D (2), was isolated from the root bark of Hibiscus syriacus. Utilizing UV, IR, NMR, and MS spectroscopic analyses, these chemical structures were revealed. Compounds 1 and 2 were found to posses significant anti-aging properties on the human neutrophil elastase (HNE) assay, exhibiting HNE inhibitory activities with IC50 values of 5.2 and 4.6 μM, respectively.-
dc.publisherKorea Soc-Assoc-Inst-
dc.titleHydroxyhibiscone A, a novel human neutrophil elastase inhibitor from Hibiscus syriacus-
dc.title.alternativeHydroxyhibiscone A, a novel human neutrophil elastase inhibitor from Hibiscus syriacus-
dc.typeArticle-
dc.citation.titleJournal of Microbiology and Biotechnology-
dc.citation.number8-
dc.citation.endPage1191-
dc.citation.startPage1189-
dc.citation.volume20-
dc.contributor.affiliatedAuthorIn Ja Ryoo-
dc.contributor.affiliatedAuthorIck Soo Lee-
dc.contributor.affiliatedAuthorJong Seog Ahn-
dc.contributor.affiliatedAuthorIck Dong Yoo-
dc.contributor.alternativeName류인자-
dc.contributor.alternativeName윤봉식-
dc.contributor.alternativeName이인경-
dc.contributor.alternativeName김영희-
dc.contributor.alternativeName이익수-
dc.contributor.alternativeName안종석-
dc.contributor.alternativeName배기환-
dc.contributor.alternativeName유익동-
dc.identifier.bibliographicCitationJournal of Microbiology and Biotechnology, vol. 20, no. 8, pp. 1189-1191-
dc.identifier.doi10.4014/jmb.1004.04028-
dc.subject.keywordHibiscus syriacus-
dc.subject.keywordHuman neutrophil elastase-
dc.subject.keywordHydroxyhibiscone A-
dc.subject.localHibiscus syriacus-
dc.subject.localHibiscus syriacus L.-
dc.subject.localHuman neutrophil elastase-
dc.subject.localhuman neutrophil elastase-
dc.subject.localHydroxyhibiscone A-
dc.description.journalClassY-
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Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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