Hydroxyhibiscone A, a novel human neutrophil elastase inhibitor from Hibiscus syriacus
Cited 12 time in 
Metadata Downloads
- Title
- Hydroxyhibiscone A, a novel human neutrophil elastase inhibitor from Hibiscus syriacus
- Author(s)
- In Ja Ryoo; B S Yun; I K Lee; Y H Kim; Ick Soo Lee; Jong Seog Ahn; K Bae; Ick Dong Yoo
- Bibliographic Citation
- Journal of Microbiology and Biotechnology, vol. 20, no. 8, pp. 1189-1191
- Publication Year
- 2010
- Abstract
- In an ongoing investigation of compounds from natural products that exhibit anti-aging properties, hydroxyhibiscone A (1), a new furanosesquiterpenoid, together with hibiscone D (2), was isolated from the root bark of Hibiscus syriacus. Utilizing UV, IR, NMR, and MS spectroscopic analyses, these chemical structures were revealed. Compounds 1 and 2 were found to posses significant anti-aging properties on the human neutrophil elastase (HNE) assay, exhibiting HNE inhibitory activities with IC50 values of 5.2 and 4.6 μM, respectively.
- ISSN
- 1017-7825
- Publisher
- Korea Soc-Assoc-Inst
- Full Text Link
- http://dx.doi.org/10.4014/jmb.1004.04028
- Type
- Article
- Appears in Collections:
- Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
- Files in This Item:
There are no files associated with this item.
Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.