Feasibility of FAIR imaging for evaluating tumor perfusion

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Title
Feasibility of FAIR imaging for evaluating tumor perfusion
Author(s)
J H Cho; G Cho; Y Song; C Lee; B W Park; C K Lee; N Kim; S B Park; Jong Soon Kang; M R Kang; Hwan Mook Kim; Y R Kim; K S Cho; J K Kim
Bibliographic Citation
Journal of Magnetic Resonance Imaging, vol. 32, no. 3, pp. 738-744
Publication Year
2010
Abstract
Purpose: To evaluate the feasibility of flow-sensitive alternating inversion recovery (FAIR) for measuring blood flow in tumor models. Materials and Methods: In eight mice tumor models, FAIR and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) was performed. The reliability for measuring blood flow on FAIR was evaluated using the coefficient of variation of blood flow on psoas muscle. Three regions of interest (ROIs) were drawn in the peripheral, intermediate, and central portions within each tumor. The location of ROI was the same on FAIR and DCE-MR images. The correlation between the blood flow on FAIR and perfusion-related parameters on DCE-MRI was evaluated using the Pearson correlation coefficient. Results: The coefficient of variation for measuring blood flow was 9.8%. Blood flow on FAIR showed a strong correlation with Kep (r = 0.77), percent relative enhancement (r = 0.73), and percent enhancement ratio (r = 0.81). The mean values of blood flow (mL/100 g/min) (358 vs. 207), Kep (sec-1) (7.46 vs. 1.31), percent relative enhancement (179% vs. 134%), and percent enhancement ratio (42% vs. 26%) were greater in the peripheral portion than in the central portion (P < 0.01). Conclusion: As blood flow measurement on FAIR is reliable and closely related with that on DCE-MR, FAIR is feasible for measuring tumor blood flow.
Keyword
AngiogenesisArterial spin labelingBlood flowFlow-sensitive alternating inversion recoveryMagnetic resonance imaging
ISSN
1053-1807
Publisher
Wiley
DOI
http://dx.doi.org/10.1002/jmri.22298
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of Bioinfrastructure > Laboratory Animal Resource Center > 1. Journal Articles
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