Mechanism of anguillosporal inhibitory activity for phospholipase C as the signal transducer in the biological networking = 생체내 정보 전달계 효소인 phospholipase C 활성을 저해하는 anguillosporal의 작용기전

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Title
Mechanism of anguillosporal inhibitory activity for phospholipase C as the signal transducer in the biological networking = 생체내 정보 전달계 효소인 phospholipase C 활성을 저해하는 anguillosporal의 작용기전
Author(s)
J W Lee; Bo Yeon KimJong Seog Ahn
Bibliographic Citation
한국지식정보기술학회 논문지, vol. 5, no. 4, pp. 19-26
Publication Year
2010
Abstract
Anguillosporal dose-dependently inhibited phospholipase C (PLC)γ1 activity in A431 cells in response to epidermal growth factor (EGF). The compound also inhibited PLCβ1 activity in α-thrombin- stimulated CCL39 cells. In accordance with this, PLCγ1 and PLCβ1 activities were also decreased by anguillosporal in vitro. However, anguillosporal did not reduce the auto- phosphorylation of EGFR and the tyrosine phosphorylation of PLCγ1 in EGF-stimulated A431 cells. Also anguillosporal did not inhibit the tyrosine kinase activity of EGFR. From these results, it is suggested that anguillosporal is a specific inhibitor of phospholipase C.
Keyword
Anguillosporalphospholipase Ctyrosine phosphorylationtyrosine kinase e
ISSN
I000-0190
Publisher
Korea Soc-Assoc-Inst
Type
Article
Appears in Collections:
Ochang Branch Institute > Anticancer Agent Research Center > 1. Journal Articles
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