Synthesis and evaluation of benzoxazole derivatives as 5-lipoxygenase inhibitors
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | H Song | - |
| dc.contributor.author | Sei Ryang Oh | - |
| dc.contributor.author | Hyeong Kyu Lee | - |
| dc.contributor.author | G Han | - |
| dc.contributor.author | J H Kim | - |
| dc.contributor.author | H W Chang | - |
| dc.contributor.author | K E Doh | - |
| dc.contributor.author | H K Rhee | - |
| dc.contributor.author | H Y Park Choo | - |
| dc.date.accessioned | 2017-04-19T09:20:01Z | - |
| dc.date.available | 2017-04-19T09:20:01Z | - |
| dc.date.issued | 2010 | - |
| dc.identifier.issn | 0968-0896 | - |
| dc.identifier.uri | 10.1016/j.bmc.2010.08.047 | ko |
| dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/9809 | - |
| dc.description.abstract | 5-Lipoxygenase (5-LOX) is important enzyme in the biosynthesis of leukotrienes, and is a potential target in the treatment of asthma and allergy. We designed and synthesized a series of benzoxazoles and benzothiazoles as 5-LOX inhibitors. Fourteen compounds prepared showed the inhibition of LTC4 formation with IC50 value of 0.12-23.88 μM. Also two compounds 2d and 2g showed improved airway hypersensitiveness. | - |
| dc.publisher | Elsevier | - |
| dc.title | Synthesis and evaluation of benzoxazole derivatives as 5-lipoxygenase inhibitors | - |
| dc.title.alternative | Synthesis and evaluation of benzoxazole derivatives as 5-lipoxygenase inhibitors | - |
| dc.type | Article | - |
| dc.citation.title | Bioorganic & Medicinal Chemistry | - |
| dc.citation.number | 21 | - |
| dc.citation.endPage | 7585 | - |
| dc.citation.startPage | 7580 | - |
| dc.citation.volume | 18 | - |
| dc.contributor.affiliatedAuthor | Sei Ryang Oh | - |
| dc.contributor.affiliatedAuthor | Hyeong Kyu Lee | - |
| dc.contributor.alternativeName | 송현민 | - |
| dc.contributor.alternativeName | 오세량 | - |
| dc.contributor.alternativeName | 이형규 | - |
| dc.contributor.alternativeName | 한균희 | - |
| dc.contributor.alternativeName | 김주헌 | - |
| dc.contributor.alternativeName | 장현욱 | - |
| dc.contributor.alternativeName | 도경은 | - |
| dc.contributor.alternativeName | 이희경 | - |
| dc.contributor.alternativeName | 박해영 | - |
| dc.identifier.bibliographicCitation | Bioorganic & Medicinal Chemistry, vol. 18, no. 21, pp. 7580-7585 | - |
| dc.identifier.doi | 10.1016/j.bmc.2010.08.047 | - |
| dc.subject.keyword | 5-LOX inhibitors | - |
| dc.subject.keyword | Airway hypersensitiveness | - |
| dc.subject.keyword | Benzoxazoles | - |
| dc.subject.local | 5-LOX inhibitors | - |
| dc.subject.local | Airway hypersensitiveness | - |
| dc.subject.local | Benzoxazoles | - |
| dc.description.journalClass | Y | - |
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