Synthesis and evaluation of benzoxazole derivatives as 5-lipoxygenase inhibitors
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- Title
- Synthesis and evaluation of benzoxazole derivatives as 5-lipoxygenase inhibitors
- Author(s)
- H Song; Sei Ryang Oh; Hyeong Kyu Lee; G Han; J H Kim; H W Chang; K E Doh; H K Rhee; H Y Park Choo
- Bibliographic Citation
- Bioorganic & Medicinal Chemistry, vol. 18, no. 21, pp. 7580-7585
- Publication Year
- 2010
- Abstract
- 5-Lipoxygenase (5-LOX) is important enzyme in the biosynthesis of leukotrienes, and is a potential target in the treatment of asthma and allergy. We designed and synthesized a series of benzoxazoles and benzothiazoles as 5-LOX inhibitors. Fourteen compounds prepared showed the inhibition of LTC4 formation with IC50 value of 0.12-23.88 μM. Also two compounds 2d and 2g showed improved airway hypersensitiveness.
- ISSN
- 0968-0896
- Publisher
- Elsevier
- Full Text Link
- http://dx.doi.org/10.1016/j.bmc.2010.08.047
- Type
- Article
- Appears in Collections:
- Ochang Branch Institute > 1. Journal Articles
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