Susceptibility for breast cancer in young patients with short rare minisatellite alleles of BORIS

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Title
Susceptibility for breast cancer in young patients with short rare minisatellite alleles of BORIS
Author(s)
S L Yoon; D C Kim; S H Cho; Sang-Yeop Lee; In-Sun Chu; J Heo; S H Leem
Bibliographic Citation
BMB Reports, vol. 43, no. 10, pp. 698-703
Publication Year
2010
Abstract
In this study, we characterized two blocks of minisatellites in the 5' upstream region of the BORIS gene (BORIS-MS1, -MS2). BORIS-MS2 was found to be polymorphic; therefore, this locus could be useful as a marker for DNA fingerprinting. We assessed the association between BORIS-MS2 and breast cancer by a case-control study with 428 controls and 793 breast cancers cases. Rare alleles in the younger group (age, <40) were associated with a statistically significant increased risk of breast cancer (odds ratio, 4.84; 95% confidence interval, 1.06-22.22; and P = 0.026). A statistically significant association between the short rare alleles and cancer was identified in the younger group (8.02; 1.01-63.83; P = 0.021). Kaplan-Meier estimates showed that poor prognosis was associated with patients who contained the rare alleles. Our data suggest that the short rare alleles of BORIS-MS2 could be used to identify the risk for breast cancer in young patients.
Keyword
BORISBreast cancerCase-control studyMinisatellite polymorphismsVNTR
ISSN
1225-8687
Publisher
Korea Soc-Assoc-Inst
DOI
http://dx.doi.org/10.3858/BMBRep.2010.43.10.698
Type
Article
Appears in Collections:
Division of Biomedical Research > Metabolic Regulation Research Center > 1. Journal Articles
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