Synthesis of (S)-(+)-decursin and its analogues as potent inhibitors of melanin formation in B16 murine melanoma cells

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Title
Synthesis of (S)-(+)-decursin and its analogues as potent inhibitors of melanin formation in B16 murine melanoma cells
Author(s)
K Lee; J H Lee; S K Boovanahalli; Y Choi; Soo-Jin Choo; Ick Dong Yoo; D H Kim; M Y Yun; G W Lee; G Y Song
Bibliographic Citation
European Journal of Medicinal Chemistry, vol. 45, no. 12, pp. 5567-5575
Publication Year
2010
Abstract
We report the synthesis of a novel series of highly potent melanin inhibitors which were obtained through structural modification of an anticancer compound S-(+)-decursinol. The in vitro inhibitory potencies of the newly synthesized compounds were evaluated against α-MSH induced melanin production in B16 murine melanoma cells. Among the compounds evaluated, compounds 2, 3, 6b, 7a, 7b, 8a and 8b emerged as highly potent inhibitors of melanin production. Besides, these compounds demonstrated significantly low cytotoxicity
Keyword
(+)-Decursin(+)-Decursinol(+)-Decursinol angelateMelanin inhibitors
ISSN
0223-5234
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.ejmech.2010.09.006
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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