Oxidative stress and antioxidants in hepatic pathogenesis

Cited 183 time in scopus
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Title
Oxidative stress and antioxidants in hepatic pathogenesis
Author(s)
H L Ha; Hye Jun Shin; M A Feitelson; Dae Yeul Yu
Bibliographic Citation
World Journal of Gastroenterology, vol. 16, no. 48, pp. 6035-6043
Publication Year
2010
Abstract
Long term hepatitis B virus (HBV) infection is a major risk factor in pathogenesis of chronic liver diseases, including hepatocellular carcinoma (HCC). The HBV encoded proteins, hepatitis B virus X protein and preS, appear to contribute importantly to the pathogenesis of HCC. Both are associated with oxidative stress, which can damage cellular molecules like lipids, proteins, and DNA during chronic infection. Chronic alcohol use is another important factor that contributes to oxidative stress in the liver. Previous studies reported that treatment with antioxidants, such as curcumin, silymarin, green tea, and vitamins C and E, can protect DNA from damage and regulate liver pathogenesis-related cascades by reducing reactive oxygen species. This review summarizes some of the relationships between oxidative stress and liver pathogenesis, focusing upon HBV and alcohol, and suggests antioxidant therapeutic approaches. ⓒ 2010 Baishideng.
Keyword
Hepatitis B virusHepatitis B virus X proteinOxidative stressAlcoholAntioxidantChronic liver disease
ISSN
1007-9327
Publisher
Baishideng Publishing Group Inc
DOI
http://dx.doi.org/10.3748/wjg.v16.i48.6035
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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