2-Hydroxycurcuminoid induces apoptosis of human tumor cells through the reactive oxygen species-mitochondria pathway = 하드록시 커큐미노이드에 의한 암세포 사멸 기전 규명

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Title
2-Hydroxycurcuminoid induces apoptosis of human tumor cells through the reactive oxygen species-mitochondria pathway = 하드록시 커큐미노이드에 의한 암세포 사멸 기전 규명
Author(s)
Young Min Han; Dae Seop Shin; Y J Lee; S A Ismail; S H Hong; Dong Cho HanByoung-Mog Kwon
Bibliographic Citation
Bioorganic & Medicinal Chemistry Letters, vol. 21, no. 2, pp. 747-751
Publication Year
2011
Abstract
2-Hydroxycinnamaldehyde (HCA) and curcumin have been reported to have antitumor effects against various human tumor cells in vitro and in vivo by generation of ROS. Aldehyde-free HCA analogs were synthesized based on the structure of curcumin, which we have called 2-hydroxycurcuminoids. The hydroxyl group of curcuminoids enhances the ability to generate ROS. 2-Hydroxycurcuminoid (HCC-7) strongly inhibited the growth of SW620 colon tumor cells with a GI50 value of 7 μM, while the parent compounds, HCA and curcumin, displayed GI50 values of 12 and 30 μM, respectively. HCC-7 was found to induce apoptosis through the reactive oxygen species-mitochondria pathway and cell cycle arrest at G2/M phase.
Keyword
ApoptosisCurcuminoidHydroxycinnamaldehydeReactive oxygen species
ISSN
0960-894X
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.bmcl.2010.11.114
Type
Article
Appears in Collections:
Division of Biomedical Research > Genome Editing Research Center > 1. Journal Articles
Division of Biomedical Research > Personalized Genomic Medicine Research Center > 1. Journal Articles
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