Two new lignans from the roots of Pulsatilla koreana

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Title
Two new lignans from the roots of Pulsatilla koreana
Author(s)
T D Cuong; T M Hung; J C Kim; J I Huh; S J Kwack; T S Kang; Jung Hee Kim; H S Jang; J S Choi; Hyeong Kyu Lee; K Bae; M S Min
Bibliographic Citation
Planta Medica, vol. 77, no. 1, pp. 66-69
Publication Year
2011
Abstract
Two new lignans, (2R,3R)-2β-(4-hydroxy-3α-methoxybenzyl)-3-(4- hydroxy-3'-methoxybenzyl) -γ- butyrolactone 2-O-(β-D-glucopyranoside) (1) and (1S,2R,3S)-dimethyl-1,2,3,4-tetrahydro-3,6,7-trihydroxy-1-(3,4- dihydroxyphenyl)naphthalene-2,3-dicarboxylate (2) together with nine known compounds (3-11) were isolated from the ethyl acetate fraction of the roots of Pulsatilla koreana. Their chemical structures were established based on physicochemical and spectroscopic data analyses. All isolates were investigated for their inhibition effects against the classical pathway of the complement system. Among them, compound 6 showed significant inhibitory activity with an IC50 value of 75.9 μM, compounds 8 and 9 had moderate effects with IC50 values of 182.2 and 166.5 μM, respectively.
Keyword
anticomplement activitylignanPulsatilla koreanaRanunculaceae
ISSN
0032-0943
Publisher
Georg Thieme Verlag Kg
DOI
http://dx.doi.org/10.1055/s-0030-1250122
Type
Article
Appears in Collections:
Ochang Branch Institute > Natural Medicine Research Center > 1. Journal Articles
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