Biological evaluation of KRIBB3 analogs as a microtubule polymerization inhibitor

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Title
Biological evaluation of KRIBB3 analogs as a microtubule polymerization inhibitor
Author(s)
Sangku Lee; J N Kim; Hyeong Kyu Lee; Kab Seog Yoon; K D Shin; Byoung-Mog Kwon; Dong Cho Han
Bibliographic Citation
Bioorganic & Medicinal Chemistry Letters, vol. 21, no. 3, pp. 977-979
Publication Year
2011
Abstract
A series of KRIBB3 analogs were synthesized by modifying substituents at aryl moieties of KRIBB3 for examining structure-activity relationships, and their inhibitory activities on microtubule polymerization were evaluated. The presence of free phenolic hydrogens in aryl moieties of KRIBB3 analogs plays an important role in inhibition of microtubule polymerization.
Keyword
Anti-mitoticCancerInhibitionIsoxazoleMicrotubule
ISSN
0960-894X
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.bmcl.2010.12.044
Type
Article
Appears in Collections:
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
Division of Biomedical Research > Personalized Genomic Medicine Research Center > 1. Journal Articles
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