Manassantin A and B from Saururus chinensis inhibit interleukin-6-induced signal transducer and activator of transcription 3 activation in Hep3B cells

Cited 23 time in scopus
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Title
Manassantin A and B from Saururus chinensis inhibit interleukin-6-induced signal transducer and activator of transcription 3 activation in Hep3B cells
Author(s)
Jong Sun Chang; Seung Woong Lee; M S Kim; Bo Ra Yoon; Mi-hye Park; S G Lee; Su-Jin ParkWoo Song LeeMun Chual Rho
Bibliographic Citation
Journal of Pharmacological Sciences, vol. 115, no. 1, pp. 84-88
Publication Year
2011
Abstract
Inhibition of interleukin-6 (IL-6) has been postulated to be an effective therapy in the pathogenesis of several inflammatory diseases. The current study was performed to examine potential effects of manassantin A and B isolated from Saururus chinensis on the IL-6-induced response to human hepatoma cells. We found that manassantin A and B inhibit signal transducer and activator of transcription 3 (Stat3) activity stimulated by IL-6. We also found that both compounds decreased IL-6-induced Stat3 phosphorylation and nuclear translocation. Both compounds blocked suppressor of cytokine signaling 3 (SOCS-3)-mRNA expression induced by IL-6. In addition, we found that Stat3 inhibitory effects of these compounds could be related to protein tyrosine phosphatase. These findings suggest that manassantin A and B could be useful remedies for treatment of inflammatory diseases by inhibiting IL-6 action.
Keyword
Interleukin-6Manassantin A and BSignal transducer and activator of transcription 3 (Stat3)
ISSN
1347-8613
Publisher
Japanese Pharmacological Soc
DOI
http://dx.doi.org/10.1254/jphs.10239SC
Type
Article
Appears in Collections:
Jeonbuk Branch Institute > Immunoregulatory materials Research Center > 1. Journal Articles
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
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