Genomic Medicine Research Center (유전체맞춤의학연구센터)732

연구분야

  • Genome-wide 유전자 발현 제어기술을 이용한 맞춤의료 기술 개발
    • Genome-wide shRNA 기반 암 치료표적 유전자 발굴 및 치료기술 개발
    • Genome-wide CRISPR 시스템 기반 암 치료표적 유전자 발굴 및 치료기술 개발
  • 후성유전체 분석 기술을 이용한 세포분화 연구 및 세포분화제어기술 개발
    • 단일세포 DNA 메틸화, 크로마틴 구조 분석 및 다양한 히스톤 변형 분석 기술 확립
    • 다양한 후성유전체 정보 분석 파이프라인 구축 및 분석 소프트웨어 개발
    • 후성유전체 분석 기반 세포분화 제어기술 개발
    • 줄기세포의 분화 과정에서 DNA methylome, Histonemodification, transcriptome 변화를 비교 분석하여 후성유전인자 상호간의 네트워크연구
    • 줄기세포 분화의 모니터링을 위한 바이오마커 개발
    • NGS를 이용한 표적치료제 내성 획득 암세포의 Transcriptome, DNA methylome, Histone modification 통합 분석
    • 항암제 내성의 지표가 되는 epimutation 동정
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Showing results 1 to 20 of 437

No. Year Title Type
1 2004

2004Article

2'-Benzoyloxycinnamaldehyde induces apoptosis in human carcinoma via reactive oxygen speciesJournal of Biological Chemistry, vol. 279, no. 8, pp. 6911-6920Dong Cho Han; Mi Young Lee; Ki Deok Shin; Sun Bok Jeon; Jung Min Kim; Kwang Hee Son; Hyoung-Chin kim; Hwan Mook Kim; Byoung-Mog Kwon
Article
2 2009

2009Article

2'-Benzoyloxycinnamaldehyde inhibits tumor growth in H-ras12V transgenic mice via downregulation of metallothionein = 2-벤조일옥시 시남알데하이드는 메탈로싸이오닌의 발현을 억제함으로써 발암유전자 라스가 도입된 형질전환 마우스의 종양성장을 억제Nutrition and Cancer-An International Journal, vol. 61, no. 5, pp. 723-734H S Lee; S Y Lee; Hye-Lin Ha; Dong Cho Han; Jong Min Han; Tae Sook Jeong; Dae Yeul Yu; Young Il Yeom; Byoung-Mog Kwon; E Y Moon
Article
3 2025

2025Article

2'-Hydroxycinnamaldehyde induces ROS-mediated apoptosis in cancer cells by targeting PRX1 and PRX2Results in Chemistry, vol. 13, pp. 101931-101931Yae Jin Yoon; Yu-Jin Lee; Jiyeon Choi; Seung-Wook Chi; Sangku Lee; Kyung Chan Park; Byoung-Mog Kwon; Dong Cho Han
Article
4 2019

2019Article

2'-Hydroxycinnamaldehyde inhibits proliferation and induces apoptosis via signal transducer and activator of transcription 3 inactivation and reactive oxygen species generation = 2’-Hydroxycinnamaldehyde는 STAT3와 ROS의 활성 조절을 통해 항암 효과Cancer Science, vol. 110, pp. 366-378Yae Jin Yoon; Young Hwan Kim; Yu Jin Lee; Jiyeon Choi; C H Kim; Dong Cho Han; Byoung-Mog Kwon
Article
5 2011

2011Article

2-Hydroxycurcuminoid induces apoptosis of human tumor cells through the reactive oxygen species-mitochondria pathway = 하드록시 커큐미노이드에 의한 암세포 사멸 기전 규명Bioorganic & Medicinal Chemistry Letters, vol. 21, no. 2, pp. 747-751Young Min Han; Dae Seop Shin; Y J Lee; S A Ismail; S H Hong; Dong Cho Han; Byoung-Mog Kwon
Article
6 2018

2018Article

2′-hydroxycinnamaldehyde inhibits cancer cell proliferation and tumor growth by targeting the pyruvate kinase M2 = 하드록시 신남알데하이드에 의한 PKM2 활성화와 항암효과Cancer Letters, vol. 434, no. 1, pp. 42-55Yae Jin Yoon; Young Hwan Kim; Yena Jin; Seung-Wook ChiJeong Hee MoonDong Cho Han; Byoung-Mog Kwon
Article
7 2021

2021Article

8-Epi-xanthatin induces the apoptosis of DU145 prostate carcinoma cells through signal transducer and activator of transcription 3 inhibition and reactive oxygen species generationPhytotherapy Research, vol. 35, pp. 1508-1520Yujin Lee; Jiyeon Choi; Yae Jin Yoon; Yugyeong Sim; Hyung Won RyuSei-Ryang OhDoo-Young Kim; Jihyun Hwang; Seung-Wook ChiDong Cho Han, et al.
Article
8 2024

2024Article

A 23-gene prognostic index predicts progression and bacillus Calmette-Guerin response in non-muscle-invasive bladder cancerEuropean Urology, vol. 85, no. 4, pp. 400-402Seon-Kyu Kim; Y J Byun; Seong-Hwan Park; X M Piao; C M Zheng; S Moon; K Kim; S J Song; H W Kang; W T Kim, et al.
Article
9 2010

2010Article

A comparison of kinetic models of foodborne pathogen inactivation by aqueous chlorine dioxide, fumaric acid, and ultraviolet-CJournal of Korean Society for Applied Biological Chemistry, vol. 53, no. 2, pp. 243-248H H Chun; H J Kim; Mi Sun Won; Kyung Sook Chung; K B Song
Article
10 2006

2006Article

A composite gene delivery system consisting of polyethylenimine and an amphipathic peptide KALAJournal of Gene Medicine, vol. 8, no. 12, pp. 1425-1434S H Min; Dong Chul Lee; M J Lim; H S Park; D M Kim; C W Cho; D Y Yoon; Young Il Yeom
Article
11 1992

1992Article

A high molecular weight, periplasmic acid protease(PAP) in Escherichia coliMolecules and Cells, vol. 2, no. 1, pp. 43-46Kyung Chan Park; Jugn Kwon Yoo; Seung Ho Kim; Kyung Soo Hahm; Doo Bong Ha; Chin Ha Chung
Article
12 2015

2015Article

A lactate-induced response to hypoxia = 젖산 매개 저산소 반응Cell, vol. 161, no. 3, pp. 595-609Dong Chul Lee; Hyun Ahm Sohn; Z Y Park; Sangho Oh; Y K Kang; K M Lee; Min Ho Kang; Ye Jin Jang; Suk Jin Yang; Young Ki Hong, et al.
Article
13 2017

2017Article

A liver-specific gene expression panel predicts the differentiation status of In vitro hepatocyte modelsHepatology, vol. 66, no. 5, pp. 1662-1674Dae Soo Kim; Jea Woon Ryu; Mi Young Son; J H Oh; Kyung-Sook ChungSugi LeeJeong Ju Lee; Jun Ho Ahn; Ju-Sik Min; Jiwon Ahn, et al.
Article
14 2013

2013Article

A novel antitumor piperazine alkyl compound causes apoptosis by inducing RhoB expression via ROS-mediated c-Abl/p38 MAPK signalingCancer Chemotherapy and Pharmacology, vol. 72, pp. 1315-1324Kyung-Sook Chung; G Han; Bo Kyung Kim; H M Kim; J S Yang; Jiwon Ahn; K Lee; K B Song; Mi Sun Won
Article
15 2009

2009Article

A novel benzimidazole analogue inhibits the hypoxia-inducible factor (HIF)-1 pathwayBiochemical and Biophysical Research Communications, vol. 385, no. 1, pp. 16-21Mi Sun Won; N Im; S Park; S K Boovanahalli; Y Jin; X Jin; Kyung Sook Chung; Kang Moo rim; Kiho Lee; Song Kyu Park, et al.
Article
16 2016

2016Article

A novel malate dehydrogenase 2 inhibitor suppresses hypoxia-inducible factor-1 by regulating mitochondrial respiration = 미토콘드리아 호흡을 저해함으로써 HIF-1을 억제하는 신규 MDH2 저해제PLoS One, vol. 11, no. 9, pp. e0162568-e0162568Hyun Seung Ban; X Xu; K Jang; Inhyub Kim; Bo Kyung Kim; K Lee; Mi Sun Won
Article
17 1997

1997Article

A novel protein, Psp1, essential for cell cycle progression of Schizosaccharomyces pombe is phosphorylated by Cdc2-Cdc13 upon entry into G0-like stationary phase of cell growthJournal of Biological Chemistry, vol. 272, no. 32, pp. 19993-20002Young Joo Jang; Mi Sun Won; Kyung Sook ChungDong Uk Kim; Kwang Lae Hoe; Chankyu Park; Hyang Sook Yoo
Article
18 2015

2015Article

A novel pyruvate kinase M2 activator compound that suppresses lung cancer cell viability under hypoxia = 저산소 상태에서 폐암 생장을 억제하는 신규 피루베이트 카이네이즈 M2 활성물질Molecules and Cells, vol. 38, no. 4, pp. 373-379Dong Joon Kim; Young Soo Park; N D Kim; S H Min; Yeon Mi You; Yuri Jung; Han Koo; Hanmi Noh; Jung Ae KimKyung Chan Park, et al.
Article
19 2020

2020Article

A novel X-linked variant of IQSEC2 is associated with Lennox-gastaut syndrome and mild intellectual disability in three generations of a korean familyGenetic Testing and Molecular Biomarkers, vol. 24, no. 1, pp. 54-58Min Hyuk Choi; Jin Ok Yang; Ju-Sik Min; Jeong Ju Lee; Soo Young Jun; Yong Jae LeeJi Yong Yoon; Su Jin Jeon; Iksu Byeon; J W Kang, et al.
Article
20 2008

2008Article

A quantitative analysis of N-myc downstream regulated gene 2 (NDRG 2) in human tissues and cell lysates by reverse-phase protein microarrayClinica Chimica Acta, vol. 387, no. 1, pp. 84-89Mi-Young Park; S C Choi; H S Lee; D K Kim; K E Baek; Jong-Tae Kim; J S Lim; Young Il Yeom; Jin Woong Chung; J W Kim, et al.
Article
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