Biotherapeutics Translational Research Center (바이오신약중개연구센터)698

연구분야

  • 암/혈관신생/혈관염증 조절 표적 발굴 및 제어 기술 개발
    • 다기능 항체 라이브러리 시스템 기반 표적 발굴 및 항체 개발
    • 줄기세포 기반 혈관내피분화조절
  • 약제내성 및 암전이 조절 규명 및 제어 기술 개발
    • 기초-임상 중개연구를 통한 신약개발
  • 암 특이적 세포대사-신호를 표적으로 한 질환 치료제 개발 및 적용기술 개발연구
    • 암세포 대사체 젖산의 역할 및 작용기전 연구
    • 젖산 신호전달체계 조절을 통한 질환 치료기술 연구
  • 면역결핍돼지 생산에 관련한 유전자 발굴
    • 면역거부반응을 일으키는 인자에 대한 메커니즘 연구
  • 질환동물 생산 및 기능적 연구
    • Gene editing system을 이용한 유전자 결손 및 변이 동물 생산
    • 동물모델을 이용한 분자유전학적 및 생리학적 기능에 대한 연구
더보기

Showing results 1 to 20 of 313

No. Year Title Type
1 2017

2017Article

14-3-3 gamma regulates Copinel-mediated neuronal differentiation in HiB5 hippocampal progenitor cellsExperimental Cell Research, vol. 356, no. 1, pp. 85-92J C Yoo; N Park; B Lee; A Nashed; Y S Lee; Tae Hwan Kim; Da Yong Lee; A Kim; E M Hwang; G S Yi, et al.
Article
2 2011

2011Article

5-(4-Hydroxy-2,3,5-trimethylbenzylidene) thiazolidine-2,4-dione attenuates atherosclerosis possibly by reducing monocyte recruitment to the lesionExperimental and Molecular Medicine, vol. 43, no. 8, pp. 471-478J H Choi; Jong Gil Park; H J Jeon; M S Kim; M R Lee; M N Lee; S K Sonn; J H Kim; M H Lee; M S Choi, et al.
Article
3 2012

2012Article

A chimeric antibody to L1 cell adhesion molecule shows therapeutic effect in an intrahepatic cholangiocarcinoma modelExperimental and Molecular Medicine, vol. 44, no. 4, pp. 293-302E S Lee; M S Jeong; R Singh; Juyeon Jung; Hyunho Yoon; Jeong Ki Min; K H Kim; H J Hong
Article
4 2023

2023Article

A critical role for ERO1α in arterial thrombosis and ischemic strokeCirculation Research, vol. 132, no. 11, pp. e206-e222V Jha; B Xiong; T Kumari; G Brown; J Wang; K Kim; J Lee; N Asquith; J Gallagher; L Asherman, et al.
Article
5 2022

2022Article

A desirable transgenic strategy using GGTA1 endogenous promoter-mediated knock-in for xenotransplantation modelScientific Reports, vol. 12, pp. 9611-9611N Ko; J Shim; H J Kim; Y Lee; J K Park; K Kwak; Jeong Woong Lee; D I Jin; H Kim; K Choi
Article
6 2019

2019Article

A functional regulatory variant of MYH3 influences muscle fiber-type composition and intramuscular fat content in pigsPLoS Genetics, vol. 15, no. 10, pp. 1008279-1008279I C Cho; H B Park; Jin Seop Ahn; S H Han; J B Lee; H T Lim; C K Yoo; E J Jung; Dong-Hwan Kim; W S Sun, et al.
Article
7 2015

2015Article

A novel human model of the neurodegenerative disease GM1 gangliosidosis using induced pluripotent stem cells demonstrates inflammasome activationJournal of Pathology, vol. 237, no. 1, pp. 98-110Mi Young Son; Jae Eun Kwak; Binna SeolDa Yong Lee; Hyejin Jeon; Yee Sook Cho
Article
8 2016

2016Article

A novel malate dehydrogenase 2 inhibitor suppresses hypoxia-inducible factor-1 by regulating mitochondrial respiration = 미토콘드리아 호흡을 저해함으로써 HIF-1을 억제하는 신규 MDH2 저해제PLoS One, vol. 11, no. 9, pp. e0162568-e0162568Hyun Seung Ban; X Xu; K Jang; Inhyub Kim; Bo Kyung Kim; K Lee; Mi Sun Won
Article
9 2016

2016Article

A novel regulatory element (E77) isolated from CHO-K1 genomic DNA enhances stable gene expression in Chinese hamster ovary cellsBiotechnology Journal, vol. 11, no. 5, pp. 633-641Shin-Young Kang; Yeon-Gu Kim; Seunghee Kang; Hong-Weon LeeEun Gyo Lee
Article
10 2016

2016Article

A phosphorylation pattern-recognizing antibody specifically reacts to RNA polymerase II bound to exonsExperimental and Molecular Medicine, vol. 48, no. 11, pp. e271-e271j Han; J H Lee; S Park; S Yoon; A Yoon; D B Hwang; H K Lee; M S Kim; Y Lee; Wonjun Yang, et al.
Article
11 2019

2019Article

A reliable approach for assessing size-dependent effects of silica nanoparticles on cellular internalization behavior and cytotoxic mechanismsInternational Journal of Nanomedicine, vol. 14, pp. 7375-7387Wooil Kim; Won Kon Kim; Kungmin Lee; Min Jeong Son; M Kwak; W S Chang; Jeong Ki Min; N W Song; J LeeKwang-Hee Bae
Article
12 2022

2022Article

A sensitive immunodetection assay using antibodies specific to staphylococcal enterotoxin B produced by baculovirus expressionBiosensors, vol. 12, no. 10, pp. 787-787Ju Hong Jang; Sungsik Kim; Seul Gi Kim; Jaemin Lee; Dong Gwang Lee; Jieun Jang; Y S Jeong; D H Song; Jeong Ki Min; Jong Gil Park, et al.
Article
13 2015

2015Article

A single-plasmid vector for transgene amplification using short hairpin RNA targeting the 3′-UTR of amplifiable dhfrApplied Microbiology and Biotechnology, vol. 99, no. 23, pp. 10117-10126Shin Young Kang; Yeon-Gu KimHong-Weon LeeEun Gyo Lee
Article
14 2012

2012Article

Aberrant L1 cell adhesion molecule affects tumor behavior and chemosensitivity in anaplastic thyroid carcinomaClinical Cancer Research, vol. 18, no. 11, pp. 3071-3078K S Kim; Jeong Ki Min; Z L Liang; Gyungmin Lee; J U Lee; Kwang-Hee Bae; M H Lee; S E Lee; M J Ryu; S J Kim, et al.
Article
15 2016

2016Article

Aberrant methylation of Meg3 in alpha1,3-galactosyltransferase knockout pig induced pluripotent stem cellsAnimal Cells and Systems, vol. 20, no. 3, pp. 130-139D J Kwon; I S Hwang; Hye Rim Kim; Y R Kim; K B Oh; S A Ock; G S Im; Jeong Woong Lee; S Hwang
Article
16 2014

2014Article

About CD45-/CD31+/CD105+ circulating cells in patients with gynecologic malignancies-responseClinical Cancer Research, vol. 20, no. 5, pp. 1394-1395H K Yu; S J Kim; Jang Seong Kim
Article
17 2011

2011Article

Acquisition of chemoresistance in intrahepatic cholangiocarcinoma cells by activation of AKT and extracellular signal-regulated kinase (ERK)1/2 = 담도암에서 항암제 내성 기전규명Biochemical and Biophysical Research Communications, vol. 405, no. 3, pp. 333-337Hyunho Yoon; Jeong Ki Min; J W Lee; D G Kim; H J Hong
Article
18 2018

2018Article

Adipose-specific expression of mouse Rbp7 gene and its developmental and metabolic changesGene, vol. 670, pp. 38-45J Ahn; Dong-Hwan Kim; Y Suh; Jeong Woong Lee; K Lee
Article
19 2021

2021Article

Altered gene expression profiles in neural stem cells derived from duchenne muscular dystrophy patients with intellectual disabilityExperimental Neurobiology, vol. 30, no. 4, pp. 263-274Jahong Koo; Subin Park; Soo Eun Sung; J Lee; Dae Soo KimJungwoon LeeJae-Ran LeeNam-Soon KimDa Yong Lee
Article
20 2021

2021Article

Amplification of EBNA-1 through a single-plasmid vector-based gene amplification system in HEK293 cells as an efficient transient gene expression systemApplied Microbiology and Biotechnology, vol. 105, no. 1, pp. 67-76Sun-Hye Park; Jong-Ho Park; Joo Hyoung Lee; Hoon Min Lee; Yeon Ju Kang; Eun Ji Lee; S Shin; G M Lee; Yeon-Gu Kim
Article
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