The Drosophila homolog of methionine sulfoxide reductase A extends lifespan and increases nuclear localization of FOXO

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Title
The Drosophila homolog of methionine sulfoxide reductase A extends lifespan and increases nuclear localization of FOXO
Author(s)
H CHung; Ae Kyeong Kim; S A Jung; S W Kim; Kweon Yu; J H Lee
Bibliographic Citation
FEBS Letters, vol. 584, no. 16, pp. 3609-3614
Publication Year
2010
Abstract
Methionine sulfoxide reductase A (msrA) was previously found to increase resistance to oxidative stress and longevity in animals. We identified Drosophila msrA (dmsrA), a Drosophila homolog of human msrA, as a downstream effector of forkhead box O (FOXO) signaling in Drosophila, which enhances resistance to oxidative stress and increases survival under stressed conditions. Additionally, overexpression of dmsrA in neurons extended the lifespan of flies. Moreover, overexpression of dmsrA in fat body cells caused FOXO to translocate to the nucleus, implying that this possible positive feedback loop between dmsrA and FOXO could potentiate the antioxidant activity of dmsrA and increase the lifespan in Drosophila.
Keyword
Antioxidant enzymeDrosophilaForkhead box OLifespanLongevityMethionine sulfoxide reductase AOxidative stressTranscriptionTranslocation
ISSN
0014-5793
Publisher
Wiley
DOI
http://dx.doi.org/10.1016/j.febslet.2010.07.033
Type
Article
Appears in Collections:
Division of Biomaterials Research > Bionanotechnology Research Center > 1. Journal Articles
Division of Biomedical Research > Disease Target Structure Research Center > 1. Journal Articles
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